Evaluation of Anti-Photoaging Effects of a Novel Cosmeceutical Containing a Retinoids Mixture Using In Vitro Cell Models

Physiological ageing due to the passing of time and prolonged exposure harmful sun rays generate wrinkles reduce skin elasticity. These visible clinical signs can be prevented or reversed by known strategies, such as daily use cosmetic products with antioxidant combinations retinoids. A new dermocosmetic formulation enriched a complex retinoids, called RETINOIDS SERUM, was investigated through in vitro assays using human cells. The experiments were carried out assess anti-ageing activity normal dermal fibroblasts (NHDF) epidermal keratinocytes (HaCaT). After preliminary MTT assay, proliferation together synthesis collagen elastin fibers performed on NHDF cells after 24 h treatment two non-cytotoxic concentrations. Using UVB-irradiated HaCaT cells, measurement matrix metalloproteinase-1 (MMP-1) levels also investigated. In studies show that product improves renewal fibroblasts. Moreover, reduction MMP-1 secretion highlighted results suggest containing functional compounds retinoids useful prevent natural sign ageing.